Bibliografía.
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· Fernández M.F., Pedraza, V., Olea, N. Estrogens in the Environment: is there a breast cancer connection?. Cáncer J. 11:11-17,1.998.
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· García Repetto R, Soria ML, Giménez MP, Menendez M, repetto M. Detaths from pesticide poisoning in Spain from 1.991 to 1.996. Veterinary Human toxicol 40:166-168,1.998.
· Gómez Ariza JL, Morales E, Giráldez I. Spatial distribution of butyltin and phenyltin compounds in Huelva Coast (Southwest Spain). Chemosphere 37:937-950,1.998.
· Guillette LT, Gross D, Gross A, Ronney H, Percival A. Gonadal steroidogenesis in vitro from juvenile alligators obtained from contaminated of control lakes. Environ Health Perspec 103:31-36,1.995.
· Groome H. Investigación agropecuaria y agricultura sustentable: algunos interrogantes. En: Genes en el laboratorio y en la fábrica. A. Duán, J Riechmann eds. Trotta Editorial, Madrid 1.998, pp 141-152.
· Gunderson EL. FDA total diet study, July 1.986-April 1.991, dietary intakes of pesticides, selected elements, and other chemicals. J AOAC Int 78:1.353-1.363,1.995.
· Heath RG, Spann JW, Kreitzer JF. Marked DDE impairment of mallard reproduction in controlled studies. Nature
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· Helzlsouer KJ, Alberg AJ, Huang H-Y, Hoffman SC et al. Serum concentrations of organochlorines compunds and the subsequent development of breast cancer. Concer Epidem Biomarker Prevention 8:525-532,1.999.
· Hernández F, Serrano R, Miralles MC, Font N. Gas liquid chromatography and enzyme-linked immune sorbent assay in pesticide monitoring of surface water from the Western Mediterranean (Comunidad Valenciana, Spain). Cromatographia 42:151-158,1.996.
· Herrera JC, Brotons M. Results of the residue monitoring programme of Andalusian agricultural department in Almería for fruits and vegetables. Second European Pesticide Residue Workshop, Almería 1.998, 154.
· Hickey JJ, Anderson DW. Chlorinated hydrocarbons and eggshell changes in raptorial and fish-eating birds. Science. 162:271-273,1.968.
· Hoyer AP, Grandjean P, Jorgensen T, Brock J, Hartving HB. Organochlorine exposure and risk of breast cancer. Lancet 352:1.816-1.820,1.998.
· IARC Monographs on the evaluation of carcinogenic risk to humans. Vol 1-69. Lyon: International Agency for Research on Cáncer, 1.972-1.997.
· Jin L, Tran DQ, Ide CF, McLachlan JA, arnold SF. Several synthetic chemicals inhibit progesterone receptor-mediated transactivation in yeast. Biophys Res Commun 233:139-146,1.997.
· Jobling S, Sumpter JA. Detergent components in sewqge effluent are weakly estrogenic to fish: An in vitro study using rainbow trout (Oncorhynchus mykiss) Hepatocytes. Aquatic Toxicol27:361-72,1.993.
· La alimentación y la agricultura. En "Recursos Mundiales. La guía Global del Medio Ambiente". Angel Muñoz ed. Ecoespaña. Ministerio de Medio Ambiente, Madrid 1.997, pp 245-271.
· Lázaro R, Herrera A, Arino A, Conchello MP, Babyarri S. Organochlorine pesticide residues in total diet samples from Aragon (Northeastern Spain). J. Agricultural Fodd Sciences 44:2.742-2.747,1.996.
· Olea N. Health effects of pesticides. En: The International Conference on Regulatory Issues in crop protection and their implications for the Food Supply. Shuman JM ed. Boston, 1.997, 38-40. · Olea N, Olea-Serrano MF: Estrogens and the environment. Cáncer Prevention J. 5:1-6,1.996.
· Olea N, Molina MJ, García-Martin M, Olea-Serrano MF: Modern agricultural practices: The human price. En: Endocrine disruption and Reproductive effects in Wildlife and Humans. Soto, A.M., Sonnenschein, C. Y Colborn, T. Eds. Comments in Toxicology, 1.996, 455-474.
· Olea N, Pazos P, Expósito J.: Inadverent exposure to xenoestrogens. Eur. J. Cáncer Preven. 7:17-23,1.998.
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· Pazos P, Olea-Serrano MF, Zuluaga A, Olea N.: Endocrine Disrupting Chemicals: Xenoestrogens. Med. Biol. Environ Int. J. 26:41-47,1.998.
· Parrón T, Hernández AF, Pla A, Villanueva E. Clinical and biochemical changes in greenhouse sprayers chronically exposed to pesticides. Hum Exp Toxicol 15:957-963,1.996.
· Parrón T, Hernández AF, Villanueva E: Increased risk of suicide with exposure to pesticides in an intensive agricultural area. A 12 year retrospective study. Forensic Sci nt 17:56-63,1.996.
· Penuela GA, Barceló D. Application of C-18 disks followed by gas chromatography techniques to degradation kinetics, stability and monitoring of endosulfan in water. J. Chromatography 795:93-104,1.998.
· Rivas A, Olea N, Olea-Serrano MF: Human exposure to endocrine-disrupting chemicals: assessing the total estrogenic xenobiotic burden. Trens Analytical. Res, 16:613-619,1.997.
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· Ruiz JM, Quintela M, Barreiro R. Ubiquotous imposex and organotin bioaccumulation in grastropods nucella-lapillus from Galicia (NW Spain)- A possible effect of nearshore shiping. Marine Ecology-progress Series 164:237-244,1.998. · Samo W. Pesticides and agriculture: Industry perspective. En: The International Conference on Regulatory Issues in crop protection and their implications for the Food Supply. Shuman JM ed. Boston, 1.997, 35-36.
· Seba DB, Snedaker SC. Frequency of occurrence of organochlorine pesticides in sea surface slicks in Atlantic and Pacific coastal waters. Mar Res 4:27-32,1.995.
· Soto AM, Chung KL, Sonnenschein C. The pesticides endosulfan, toxaphene and dieldrin have estrogenic effects on human estrogen sensitive cells. Environ Health Perspect 102:380-383,1.994.
· Soto AM, Sonnenschein C, Chung KL, Fernández MF, Olea N, Olea-Serrano MF.: The E-Screen as a tool to identify estrogens: An update on estrogenic environmental pollutants. Environ. Health Perspect., 103:113-122,1.995.
· Statement from the work session on health effects of contemporary-use pesticides: the wildlife/human connection. Toxicol Industrial Health 15:1-5,1.999.
· Torres CM, Pico Y, Redondo MJ, Manes J. Matrix solid phase dispersion extraction procedure for multiresidue pesticide analysis in oranges. J. Choromatography A 719:95-103,1.996.
· Vidal JLM, González FJE, Glass CR, Galera MM, Cano MLC. Analysis of lindane, alpha, endosulfan, beta-endosulfan and endosulfan sulfate in greenhouse air by gas chromatography. J Chromatography A 765:99-108,1.996.
· Vonier PM, Crain DA, MacLachlan JA, Guillette LJ, Arnold SF. Interactions of environmental chemicals with the estrogen and progesterone receptors from the oviduct of the American alligator. Environ Healt Perspect 104:1.318-1.322,1.996.
· Weidner IS, Moller H, Jensen TK, Skakkebaek NE: Cryptorchidism and hypospadias in sons of gradeners and farmers. En viron Health Perspect 106:793-796,1.998.
· Wolff MS, Toniolo PG, Lee EW, Rivera M, Dubin N. Blood levels of organochlorines residues and the risk of the breast cancer. J Natl Cancer Inst. 85:648-652,1.993.
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TABLA 1: DISTRIBUCIÓN PARCELARIA EN EL EJIDO.
Tamaño de parcela (m2). Número de parcelas 15.000 692 Número de parcelas /Propietario Número de propietarios 1 7.233 2-4 1.930 > 4 125
TABLA 2. COMPUESTOS QUÍMICOS DISRUPTORES HORMONALES.
Grupo Disruptores Endocrinos Organohalogenados Dioxinas, furanos, PCBs, PBBs, octacloroestireno, hexaclorobenzeno, pentaclorofenol, bromobisfenol, etc. Pesticidas 2,4,5-T, 2,4-D, alocloro, aldicarb, amitrole, atrazina, benomil, b-HCH, carbaril, clordano, cipermetyrín, DBCP, DDT y metabolitos, dicofol, dieldrín, endoslfán esfenvalerato, etilparatión, fenvalerato, lindano, heptacloro, h-epóxido, keltano, kepona, malation, macozeb, maneb, metomil, metoxicloro, metiran, metribuzin, mirex, nitrofen, oxiclordano, permetrín, piretróides sintéticos, toxafeno, transnonacloro, tributilin, trifluralin, vincozolina, zineb, ziran. Metales pesados Cadmio, mercurio, plomo Ftalatos Di-etilhexilftalato, butilbenzilftalato, di-n-butilftalato, di-n-pentilftalato, di-hexilftalato, di-propilftalato, diciclohexilftalato, dietilftalato. Bisfenoles Bisfenoles, BADGE, bis-DMA Alquilfenoles Penta a dodecilfenol Otros Estirenos, benzopirenos, ácido amsiónico, fenilfenol, butilhidroxianisol, parabenes.
